How can cancer and cancer cells be understood through the lens of cellular metabolism, and what insights can be gained into various forms of treatment? Many studies suggest that metabolic changes and the environment in which the cells inhabit can significantly impact how they function.
Listen in to learn:
Oncologist and cancer researcher at the Koch Institute at MIT, Dr. Matthew Vander Heiden, shares his research experience and some surprising cellular processes that can dramatically impact cancer cells.
Dr. Vander Heiden sheds light on the Warburg effect, which describes how cancer cells tend to uptake glucose and ferment it rather than burning it in respiration. The fermentation of glucose rather than respiration is revealed to be how FDG PET scans function by differentiating cancer cells that use more sugar and show up highlighted on the scan. The fermentation process ultimately produces ATP and lactate to fuel the cancer cell.
Alongside development pathways for the cells, oxygen is also a limiting factor on cancer cells, and the lack or surplus will encourage particular pathways to be used. Due to the availability of particular nutrients in different regions of the body, it is also thought that an individual’s diet can impact the development of cancer cells. This is explained the clustering and absorption of those nutrients at different concentrations throughout the body.
For more information, visit https://ki.mit.edu.
Episode also available on Apple Podcasts: apple.co/30PvU9C